I've seen this before but haven't really gone back out to find an updated file to use since I've formatted a few times over the years.
There is a file on your machine called a "hosts" file. We use this a lot for programming websites. Well, you can use this file to block the majority of Spyware and PopUps that come up on your browser.
I know i know, "I already have a popup blocker". Yep, but do you have a "Ads" blocker? Blocking those annoying Flash and/or animated ads from annoying the hell out of you? This is what this file does.
I went out and found a fellow by the name of Mike that has been keeping an up-to-date file that you can download. Mike explains it best on his site:
http://everythingisnt.com/hosts.html
You can also just download the file manually here:
http://everythingisnt.com/hosts (best to right-click and save as).
If you don't know what to do with this file, resort to the first link above.